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Aging Pathobiology and Therapeutics, 2019, 1(1): 0509

The knock-in was additionally validated by Sanger sequencing and Synthego analysis tool ( analysis with the following Primers: amplification: CCGACTGGTGCATCTCCTTT and GAGAGCCTGTAATGCTAGGCAG sequencing: GAGAGCCTGTAATGCTAGGCAG

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It is evident that the plaque reduction efficiency highly correlates with the BBB-opened area and exposure frequency, as hemisphere opening induced a ~20% plaque reduction 6 whereas whole brain exposure induced ~75% plaque reduction 7