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Active acne vulgaris, chronic follicular congestion, and post-acne structural defects, including atrophic, rolling, or ice-pick acne scars

J Psychopharmacol 35(12):14641472 Fernndez A, Rodriguez-Palancas A, Lpez-Ibor M et al (2005) Increased occipital delta dipole density in major depressive disorder determined by magnetoencephalography

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As stated elsewhere, this is prominently featured in the free radical theory of aging, introduced by Harman in 1954 and later revised as the mitochondrial free radical theory of aging, which links OS and mitochondrial dysfunction to aging-related changes [56]

Additionally, the presence of perinuclear antineutrophil cytoplasmic antibodies (ANCA) has emerged as a potential biomarker for disease activity