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Other Affiliation: Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, USA Tiwari, Hemant ORCID: Other Affiliation: Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA Turman, Constance ORCID: Other Affiliation: Department of Epidemiology, Harvard T.H

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Subclusters 2 and 3 were both enriched for immune response-related genes, with subcluster 2 (Inflammatory Microglia) highly expressing genes involved in inflammation, such as TLR2

Its estimated that half of todays smokers will die prematurely, losing, on average, ten years of life