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However, when fat dysfunction occurs in the body, the persistence of inflammation in the body interrupts the normal process of lipolysis, leading to multiple organ damage and dysfunction, causing a series of metabolic dysfunction-related diseases [43,44,45] (such as T2DM, IR, hypertension, and CVD), and inducing MetS [46, 47]

14 A so-called therapeutic misadventure phenomenon, as coined by Zimmerman et al ., is becoming increasingly acknowledged, as some patients have presented with acute liver failure despite consumption of safe doses of APAP

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