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Lee, S.-I

Active Akt phosphorylates multiple targets including Bad (preventing it from inhibiting anti-apoptotic Bcl-2), MDM2 (stabilizing p53), FOXO transcription factors (preventing pro-apoptotic gene expression), mTOR (promoting protein synthesis)

doi: 10.1038/s41380-023-02017-y, 51 JeongJ.AhnK.MunS.YunK.KimY

Intracellular iron retention, reduced glutathione (GSH) content, and lipid reactive oxygen species (ROS) accumulation are the main characteristics of ferroptosis (Dixon et al., 2012)

The accumulation of autophagosomes early after TBI reflects a deleterious effect in which impaired lysosomal function and autophagosome clearance lead to the accumulation of ubiquitinated proteins and protein aggregates, resulting in neuronal cell death