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As shown in the table, the glucose transporter and transferrin receptor are the two most extensively investigated transport processes for developing brain targeting drug delivery systems while the GSH transporter-mediated process was the least studied of the four

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On the other hand, if uncontrolled, the enormous increase in the ROS levels inserts negative oxidative influences on cellular proteins, lipids and nucleic acid, ultimately leading the affected cell towards controlled programmed cell death (PCD) [89]