Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin
And wanted to double check with you about COSRX BHA Blackhead Power Liquid that contains 4% natural BHA component of Betaine Salicylate which is (according google info) twice as gentle as salicylic acid, i.e
Intake of niacin, folate, vitamin B-6, and vitamin B-12 through young adulthood and cognitive function in midlife: the Coronary Artery Risk Development in Young Adults (CARDIA) study
Protective effects of syringic acid, resveratrol and their combination against isoprenaline administered cardiotoxicity in wistar rats
Left unchecked, it can put significant strain on your heart and other organs, making early diagnosis and treatment essential