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Anthony Didato, DMD Larazotide Acetate Tight Junction Modulator Larazotide acetate is a synthetic peptide that modulates intestinal tight junctions, reducing intestinal permeability (leaky gut)

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However, observed barrier defects and associated diarrhea even in these mice did not result in changes in claudin-1, -2, -3, and -4 expression and cellular distributions, but rather correlated with the rearrangement of cellular distribution of occludin, and to some extent with JAM proteins

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