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Moreover, animal studies have shown that complete inhibition of BACE1 activity results in an elimination of A in neurons, but A is required for certain physiological neuronal functions such as regulation of neuron-glia signaling by enhancing spontaneous astrocyte calcium transient signaling via 7-nAChRs (Lee et al., 2014), activation of M2 microglia cells after SCI promoting plasticity, axonal outgrowth and inhibition of inflammation (Kigerl et al., 2009

Histopathological analysis supported the clinical and planimetric data

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A larger proportion of the blood vessel network disappeared, in particular at the dorsal side (Figures 3, 5 and 6)