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In contrast to the CD4+ and CD8 + T cell phenotypes observed, Ghergurovich et al

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pylori have higher levels of IL-18 and IFN-, IFN- promotes the cellular synthesis of IL-18, by boosting the production of caspase-3, the intracellular cysteine protease ICE (caspase-1) contributes to the processing of IL-18s active form and to the induction of apoptosis in gastric epithelial cells (Shimada et al., 2008