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Fourth, apply in vivo models to explore the therapeutic effect of microbiota-targeting treatments (such as metabolite supplements and microbial engineering) to restore iron homeostasis and ameliorate the OA progression and put forward evidence for clinical trials

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J Trad Chin Med Sci 7(2):141147 Bahramrezaie M et al (2019) Effects of resveratrol on VEGF & HIF1 genes expression in granulosa cells in the angiogenesis pathway and laboratory parameters of polycystic ovary syndrome: a triple-blind randomized clinical trial

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A decreased response of T cells to antigens, downregulated functioning of natural killer (NK) cells, and altered cytokine profile have also been reported in numerous studies (Lorusso et al