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A local synthesis of estradiol by endometriotic tissue is suggested by the evidence of increased aromatase activity, associated with an overexpression of cyclooxygenase 2 (COX2) and increased prostaglandins

Male SD rats were administered a single IM injection of blank solvent (excipient), and biological samples, including whole blood, plasma, urine, feces, and tissues, were collected for background control

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Arachidonic acid is metabolised via the 5-lipoxygenase pathway to leukotrienes or the cyclo-oxygenase pathway to prostanoids (prostaglandins, thromboxanes, prostacyclins)

The final decision on when to stop and resume medications should always be made in consultation with healthcare providers who are familiar with the patients medical history and the specifics of the planned surgery