Amounts of vitamin B12 that are recommended by the Food and Nutrition Board, National Academy of Science-National Research Council for lactating women (4 mcg daily) should be consumed during lactation
Starting at the lower end (200-250mcg) allows tolerance assessment and side effect minimization before increasing to therapeutic doses, while taking doses higher than prescribed does not necessarily lead to additional benefit and may increase the risk of side effects due to physiologic feedback mechanisms
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[83] These observations led to a theory that in humans, inadequately carboxylated MGP, due to low dietary intake of the vitamin, could result in increased risk of arterial calcification and coronary heart disease
Infusion time and drip speed matter as well