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New delivery mechanisms, such as microneedle patches, sustained release implants, and targeted liposomal carriers, are being developed to enhance tissue targeting and minimize dosing frequency

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However, in MCAS, these cells become highly unstable and overly sensitive, inappropriately degranulating and flooding the body with histamine in response to benign triggers like food, temperature changes, or even emotional stress

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The research question: Can topically or systemically applied peptides reverse or slow these processes by targeting specific molecular mechanisms of skin aging