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By putting everything into context by describing the BBB structure, emphasizing how the barrier alters in age and disease, and the current drugs explored to slow the negative outcomes of age and disease through acting directly on the BBB, the goal is to exploit the easily accessible and manipulable microbiota as a potential target to modulate the BBB

Equinins The antimicrobial activity of equinins (with the exception of eNAP-2) has not yet been proven, but they are able to selectively inhibit the microbial proteinases subtilisin and proteinase K

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The most common adverse events are gastrointestinal in nature, including nausea (20-47% depending on dose), constipation (21%), fatigue (20%), and vomiting (8%)