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The control group received vehicle treatment, while the treatment groups were administered either 10 mg/kg J10 or 20 mg/kg RK-33 via oral gavage on days 1, 3, and 5 per week, continuing until day 21

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By June 2021, synthetic opioids were involved in an estimated 87% of opioid deaths and 65% of all drug overdose deaths.(5) This has made opioid overdose a leading cause of death in the United States.(6) Figures 1 and 2: NIDA, Drug Overdose Deaths: Facts and Figures, Fentanyl Fentanyl is 50 times more potent than heroin and 100 times more potent than morphine

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Frontiers in Nutrition, 9(June), 122