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Alterations of bone biomechanical properties can contribute to osteoporosis and increase the risk of fractures in the elderly

However, this effect isn't directly through GCG receptor but through another protein called FGF21, which is secreted by the liver

High doses of B12, often used to treat deficiencies, may cause side effects such as headaches, nausea, diarrhea, fatigue or weakness, and tingling in the hands and feet

Label information also notes storage at controlled room temperature and protection from light

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