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The disorder is classified into two main subtypes: bipolar I disorder (BP-I), defined by the presence of at least one full manic episode, and bipolar II disorder (BP-II), characterized by hypomanic episodes without progression to full mania (Grande et al., 2016)

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Furthermore, for the first time, we revealed that PQQ could ameliorate the memory deficits and neurotoxicity induced by D-gal via binding with excess glutamate, inhibiting oxidative stress, and eliminating inflammation through GSK-3/Akt signaling pathway