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Discussions The major finding of this study carried out on varicose vein samples harvested from obese and non-obese patients undergoing cryostripping surgery is that in vitro incubation with the active vitamin D mitigated the venous oxidative stress in varicose veins and modulated the expression of nitric oxide synthase isoforms

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To thoroughly assess any potential side effects associated with MT-II, such as changes in weight or general behavior, normal C57BL/6J mice underwent a longer, fourteen-day continuous ICV administration of MT-II at the same daily dose