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The 2020 systematic review by Galeano and colleagues across 34 eligible studies confirmed the mechanism: PDRN promotes physiological tissue repair through salvage-pathway nucleotide recycling and A2A receptor activation [32]

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It could be expected that abrupt arousal may have led to enhanced breathing but as this did not appear to happen it is likely that GSHee interacted directly with the neural pathways/cellular mechanisms responsible for fentanyl-induced OIRD