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L-carnitine-mediated tumor cell protection and poor patient survival associated with OCTN2 overexpression in glioblastoma multiforme
The GSH-Fe-S cluster-OXPHOS axis GSH is indispensable for mitochondrial homeostasis and the biogenesis and stability of Fe-S clusters, thereby sustaining OXPHOS and cellular energy metabolism 16,17,203
These linkers are designed to be relatively stable at physiological pH (~7.4) but undergo hydrolysis in the acidic endosomes or lysosomes (pH 4.56.0) of tumor cells
Studies have indicated that PEG-BCT-100 is well tolerated in HCC, and the clinical benefits of ASS-negative patients are significantly superior to those of ASS-positive patients
It is widely used in in-vitro experimental models focused on proteinpeptide interactions, cellular regeneration pathways, mitochondrial activity, and receptor-binding behavior
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