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While its ability to influence multiple pathways of repair is supported by compelling preclinical data, the absence of high-quality human trials, the FDAs strict regulatory stance, and the risk of contamination from unregulated sources raise serious safety and legal concerns (including malpractice concerns and fines)

A post-hoc analysis suggested that oral lipoic acid supplementation may reduce neuropathic symptoms particularly in subjects with a high burden of cardiovascular disease, diabetes, and neuropathy yet with normal body mass index (BMI) and blood pressure (79)

fainting or feeling dizzy

Each estrogen spike can release a wave of histamine, and each histamine wave can stoke another estrogen surge

liver enzyme alterations are very frequent in PAC treated patients, even at routine dosage