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One of the main ways that progressive tubular and interstitial fibrosis occurs is through apoptotic death and the buildup of ECM (37, 38)
Apart from visual problems, i.e., retinitis pigmentosa and/or optic atrophy, and hearing loss, this cohort of 13 unrelated patients also had other clinical features such as hypotonia, global developmental delay, axonal sensorimotor polyneuropathy, regression after febrile illness, ataxia, failure to thrive, progressive microcephaly, and encephalopathy [85]
Current knowledge on endocrine disrupting chemicals (EDCs) from animal biology to humans, from pregnancy to adulthood: highlights from a national italian meeting
Microbial metabolites, postbiotics, and intestinal epithelial function