According to Liu, B.s 2020 study, Maternal cigarette smoking before and during pregnancy and the risk of preterm birth: A dose-response analysis of 25 million mother-infant pairs, examining over 25 million mother-infant pairs, while the overall preterm birth rate was 9.3% (2,378,398 cases), smoking during just the first trimester significantly increased this risk
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The Centers for Disease Control and Prevention reports that smoking any substance increases the risk of lung cancer, COPD, and heart disease
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[76] Glucuronidation and oxidative metabolism of nicotine to cotinine are both inhibited by menthol, an additive to mentholated cigarettes, thus increasing the half-life of nicotine in vivo