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In cultured fibroblasts, GHK-Cu increased collagen synthesis at strikingly low concentrations the effect began between roughly 10 -12 and 10 -11 M and peaked near 10 -9 M, independent of any change in cell number, meaning the peptide upregulated matrix production per cell rather than simply growing more cells

Five additional peptides LL-37, GHK-Cu, Dihexa acetate, Melanotan II, and PEG-MGF are scheduled for a second PCAC meeting to be held before the end of February 2027

Neuron 43 , 871881 (2004)

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