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Its a common experience that often points to something happening on a cellular level

48, 49 However, claudin-2 also serves other diverse functions including paracellular passage of cations (including sodium and calcium), cell proliferation and autophagy, and loss of claudin-2 along with claudin-15, yet another TJ protein implicated in paracellular Na + passage, results in premature death because of malnourishment in mice

Antonoff MB, Ragalie W, Sepesi B, Roth J, Walsh GL, Hofstetter W, Swisher S, Rice DC , Vaporciyan A, Mehran R

6 Bioanalysis (2013) Detection and quantification of dermorphin and selected analogs in equine urineRichards, Cawley & Raftery (PMID 24320126)

An analysis of the coronary vascular responses to catecholamines, using a modified Langendorff heart preparation