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The most important limitation is that when we correct the p-value with the false discovery rate, we observed that some suggestive p-values in different genes become non-suggestive, but it is important to resemble that a non-suggestive association cannot be deduced only by a p-value because it could be easily modified

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After nicotine binds to the receptor, it becomes persistently depolarized and cannot be activated again for a short period, even if another agonist molecule binds to it during that time