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Moreover, there is no clear evidence that quitting smoking reduces the frequency or intensity of CH attacks, suggesting a more complex relationship between smoking and CH involving genetic or neurobiological factors [87, 88]

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X-Files: Cigarette-Smoking Man's (Possible) Backstory Explained Season 4, episode 7 of The X-Files , titled "Musings of a Cigarette-Smoking Man," sees Fox Mulder's conspiracy theorist buddies The Lone Gunmen regale Mulder and Scully with information they've uncovered that they believe reveals CSM's past

Circa 1920s to 1930s