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Lincoff, A

van SadelhoffJHJMastorakouDWeenenHStahlBGarssenJHartogA

However, intracellular self-assemblies often lead to irreversible accumulation and end-effect cellular responses for therapeutic applications 21,22,23 , including mechanical stress, homeostasis disruption and eventual cell death

Methylenetetrahydrofolate donates the C1 center required for the biosynthesis of dTMP (2-deoxythymidine-5-phosphate) from dUMP (2-deoxyuridine-5-phosphate)

[175] reported that after treatment of rat primary neurons with methotrexate, a folate antagonist, the levels of PP2A methylation decreased and phosphorylated tau, APP, and -secretase were increased