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Interestingly, ACE2 may not be involved in all processes induced by the spike protein

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Children with rare mutations in the CBS or MTR genes can have neural tube defects, early atherosclerosis, or neurological effects.[ref] Related article : MTHFR and the methylation cycle Sex, age, and smoking: Men tend to have higher homocysteine levels than women, and homocysteine levels in both sexes tend to increase slightly with age