healthcare gov tobacco use and nicotine cessation: Booklet for professionals - PAHO/WHO Fact Sheets and Reports –

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Abstract As a parasympathetic alkaloid and the main substance in cigarette smoke, nicotine modulates the immune system, inhibits innate and acquired immunity and is used in treating many autoimmune diseases

Also, as with most addictive substances, there are some side effects of withdrawal

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[77] Smoking is more prevalent in males, with 36.7% of males over the age of 15 smoking, compared to 7.8% of females aged 15 or over