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This is in fact a central tenet of the ability of Fur proteins to orchestrate a graded response to increasing degrees of cellular metal limitation, where differentially metal-ligated states differentially repress the expression of downstream genes as metal levels incrementally fall in the cell

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Intraperitoneal or oral administration inhibited bladder cancer cell migration and invasion and reduced the formation of distant metastases, through mechanisms involving cellular metabolic regulation and downregulation of metastasisrelated proteins