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As Schwann cells are the most abundant glial cells in the peripheral nervous system, are major producers of both neurotrophins, and acquire a repairing phenotype after a nerve is damaged [68], it is plausible to hypothesize that the effects of cortistatin in neurotrophins are exerted through these cells

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That is, when sleep need (delta power) is already increasing (post-siesta wakefulness or during SD), NAC further augments it

Presence of three types of ligand-gated glutamate ion channel receptors such as N-methyl-D-aspartate, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, and kainite receptors has been known for a long time