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For example, in the case of ECs, each cell type, either cardiac or vascular, might have a preferential matrix for optimal culturing, and depending on the objective of the study, the microfluidic composition and dynamics must also be adjusted [270]

In a transgenic mouse model of mutant alpha-synuclein (A53T), experiments showed that alpha-synuclein accumulation in astrocytes affected glutamate transport, triggering a rise of extracellular glutamatergic concentrations and excitotoxicity, which further exacerbated damage to dopaminergic neurons (Sarafian et al., 2017)

Antelmann and Helmann, 2011

10.1212/wnl.47.1.1 134 LitvanI.AgidY.JankovicJ.GoetzC.BrandelJ.LaiE.et al (1996)

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