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Accumulating evidence indicates that mitochondrial dysfunction is a consistent hallmark of declining oocyte quality and follicular competence during aging [269]

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Additionally, IL-10 promotes EP4 protein, which helps suppress inflammation triggered by macrophages [86]

Homocysteine, as a component of the one-carbon cycle, can be converted to methionine via the trans-methylation pathway or cysteine via the trans-sulfuration pathway 15,35

Studies have indicated that the increase of the autophagy level in vivo can lead to the degradation of ferritin and the increase of iron level, thus leading to oxidative damage of cells through the Fenton reaction [66, 67]