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## GHRP vs GLP-1: Head-to-Head Comparison for Bodybuilding | Parameter | GHRP-2/6, CJC-1295, Ipamorelin | Semaglutide | Tirzepatide | Retatrutide | |-----------|--------------------------------|-------------|-------------|-------------| | **Primary Mechanism** | Indirect GH release | GLP-1 receptor agonism | GLP-1 + GIP agonism | GLP-1 + GIP + Glucagon | | **Fat Loss Evidence** | Anecdotal, no Phase III trials | 1517% (STEP trials, *Nature Medicine*) | Up to 22.5% (SURMOUNT, *NEJM*) | Up to 24.2% (Phase 2, *The Lancet*) | | **Muscle Preservation** | Claimed, not proven in trials | ~6075% of loss is fat | Potentially superior (GIP effect) | Best profile (GIP + glucagon) | | **Appetite Effect** | GHRP-6 increases hunger significantly | Powerful appetite reduction | Strong appetite reduction | Strong appetite reduction | | **Visceral Fat Targeting** | Not specifically demonstrated | Demonstrated in clinical trials | Demonstrated in clinical trials | Enhanced by glucagon receptor | | **Clinical Evidence Level** | Low (small studies, animal data) | Very High (10,000+ participants) | Very High (5,000+ participants) | High (Phase 2 completed) | | **FDA Status** | Category 2 (banned) | FDA-approved | FDA-approved | Phase 3 ongoing | | **Injection Frequency** | 13x daily | Once weekly | Once weekly | Once weekly | | **Alibaba Availability** | Banned | Available | Available | Available | ## Addressing the Muscle Loss Concern: GLP-1 Peptides and Lean Mass The biggest concern bodybuilders have about GLP-1 peptides for fat loss is muscle loss

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[DOI] [PubMed] [Google Scholar] 44.Lindor K.D., Kowdley K.V., Luketic V.A.C., Harrison E.M., McCashland T., Befeler A.S., Harnois D., Jorgensen R., Petz J., Keach J., et al

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