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Animal studies show significant improvements in body composition, metabolic markers, and muscle function with minimal adverse effects

They assessed the global alterations caused by a drug (i.e., toxicity index) presence and the degree of participation of any of the aforementioned mechanisms of hepatotoxicity

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It does not replace medical advice or prescribing decisions

Given the abnormalities of the melatonergic system in schizophrenia, the correction of sleep and circadian rhythms using melatonin administration in treatment of patients with schizophrenia might be a clinically meaningful approach, but the evidence for efficacy remains preliminary, and there are no recent studies