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While oral substitutes have shown some effectiveness according to studies, their ability to match the efficacy of intramuscular vitamin B12 remains uncertain

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This is a significant gap in the literature and represents a genuine safety concern

Moreover, following 13 C-glucose tracing in activated Gclc fl/fl and Gclc fl/fl Mb1-Cre + FoB, we detected an increased contribution of glycolytic carbon to lactate within the mutant cells (Fig