Spondylocheiro dysplastic form of the Ehlers-Danlos syndromean autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13
(2018) illustrated that intravenous injection of CRISPR-Cas9 plasmids encoding gRNAs that target NE were encapsulated into the cationic lipid-assisted nanoparticles (CLANpCas9/gNE) successfully diminished expression of NE in epididymal white adipose (eWAT) and in the liver, whereby they successfully mitigated the insulin resistance of T2D [146]
Wang, Z, Yang, B, Zhang, M, Guo, W, Wu, Z, Wang, Y, Liu, Y, Zhang, W, Akbani, R, Broom, BM, Ju, Z, Kanchi, RS, Korkut, A, Li, J, Liang, H, Ling, S, Liu, W, Lu, Y, Mills, GB, Uppore Kukkillaya, AR, Weinstein, JN, Zhang, J, Liu, X, Wang, L , Carvalho, AL, Fregnani, JG, Reis, RV, Scapulatempo, CN, Ajani, JA, Behrens, MC, Bondaruk, J, Broaddus, R, Czerniak, BA, Esmaeli, B, Fujimoto, J, Gershenwald, JE, Guo, CC, Lazar, A, Logothetis, CJ, Meric-Bernstam, F, Moran, C, Ramondetta, LM, Rice, DC, Sood, AK, Tamboli, P, Thompson, T, Troncoso, P, Tsao, A, Wistuba, II, von Deimling, A
Lee et al., 2006
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