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Abbreviations CO-Hb: Carbon monoxide-hemoglobin CNS: Central nervous system GRADE: Grading of Recommendations, Assessment, Development, and Evaluations nACHRs: Nicotinic acetylcholine receptors OR: Odds ratio PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses References Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M

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Of course, as more evidence accumulated to show that tobacco was not medicinal, marketers reframed filtered and menthol cigarette products not as medicine, but as a kind of therapeutic smoke

With a sly grin, Brady jumped into a tale of the first time he tried chewing tobacco when he was young kid

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