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Nevertheless, most individuals have DKD, which results in diseases such as anemia, nerve damage, and fatigue

moderate quality evidence) (El Sharkwy & Sharaf El-Din, 2019)

The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment

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