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10.1007/s00213-018-5090-6 15 DengH.JiaY.PanD.MaZ

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This enhancement is demonstrable through an increase in mitochondrial DNA content, the upregulation of genes integral to mitochondrial biogenesis, and the increased expression of proteins pivotal in oxidative phosphorylation

It is non-essential and conditionally essential in humans, meaning the body can usually synthesize sufficient amounts of it, but in some instances of stress, the body's demand for glutamine increases, and glutamine must be obtained from the diet

It does not replace the training stimulus required for muscle development or the caloric structure required for meaningful fat loss