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Although the permeability value of targeted nanocarriers were lower in case of BBB models on the inserts with 0.4 m pore size membranes, the significant difference between the non-targeted and targeted groups remained the same and the penetration of marker molecules across the BBB model on inserts with 3 m pore-size membranes or 0.4 m pore-size membranes were also similar

Itkin et al., 2016

2020 doi: 10.1016/j.jmii.2020.03.022

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Also, the amino acid L-methionine plays a vital role in the production of cysteine, so if this is in short supply, again the chain reaction is affected