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Studies on patients with hyperplastic thyroid diseases before and after surgery showed cell immunity imbalances, particularly in lymphocyte subpopulations and immunoregulatory indices, which worsened post-operation

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Rapid correction of glycaemia with resultant optic nerve swelling has been hypothesised as a factor

Biochimica Biophysica Acta 1832 (6), 805816

Key facts from Pickarts original studies: GHK-Cu exists in the plasma of all healthy adults The concentration decreases with age , from ~200 ng/ml in 20-year-olds to ~80 ng/ml in 60-year-olds This decline correlates with the age-related loss of regenerative capacity of tissue Cu is essential for the biological activity, GHK without copper has a dramatically weaker effect These original observations launched a 50-year research program that today covers thousands of publications in dermatology, wound healing, ageing research and regenerative medicine