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Exclusion criteria Articles fulfilling the following criteria were excluded from the present study: i) Randomized trials without a placebo or control group

The overall treatment discontinuation rate is lower with cagrilintide (about 1%) compared to semaglutide (5-7%)

Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection

One contributing factor may be the substantial differences in drug metabolism between rodents and humans