Liu R, Sun L, Shi X et al (2024) Increased expression of KNa1.2 channel by MAPK pathway regulates neuronal activity following traumatic brain injury
Notably, senkyunolides, core bioactive compounds derived from traditional anti-migraine herbs like Ligusticum chuanxiong , have emerged as promising candidates due to the role of multidimensional homeostasis in regulating neurovascular units (suppressing activation of the trigeminal vascular system, modulating pathological vascular alterations, modulating neurotransmitters and receptors, inhibiting inflammatory response, antioxidant stress and analgesic effects and improving blood-brain barrier integrity) and unique pharmacokinetic advantages (small-molecule structure enabling blood-brain barrier penetration, natural origin reducing hepatorenal toxicity risks)
Nutritional Facts Warning Do not exceed the recommended daily dosage
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Semaglutide acts on one gut hormone (GLP-1), while tirzepatide acts on two (GLP-1 and GIP)