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This hormonal effect accounts for sexual characteristics changes in immune function, and the higher susceptibility of women to autoimmune diseases like SLE ( It will be crucial to distinguish the interplay of gut microbiota and the sex hormones as it can potentially unlock the mechanisms of higher susceptibility of females to SLE and also unveil novel avenues of therapeutic intervention by manipulation of the gut microbiome for controlling disease course ( 3 Probiotics and systemic lupus erythematosus Probiotics are live microorganisms significant for their role in immunomodulation in SLE patients, as they restore gut microbiota balance and enhance immune function

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Thrombin Peptide 508 (Chrysalin) Thrombin peptide 508 (TP508), also known as Chrysalin, is a 23-amino acid synthetic peptide that represents the non-proteolytic receptor binding domain of thrombin

Therefore, targeting the System Xc /GSH/GPX4 axis while minimizing side effects represents a major ongoing challenge and a key direction for future PDAC therapy