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Germ-free (GF) mouse models demonstrate impaired intestinal epithelial turnover and diminished regenerative capacity upon injury 6 , underscoring the essential role of gut microbiota and their metabolic byproducts in post-damage tissue repair

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In dopaminergic neurons, which are diminished in PD patients, ACE2 is significantly expressed and may contribute to the aggravation of pre-existing symptoms or a more severe COVID-19 infection [38]

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