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The genes encoding these enzymes are known to be highly polymorphic

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Additionally, data from the phase 3 TROPION-Lung01 trial published in the Journal of Clinical Oncology revealed that dato-DXd showed a progression-free survival (PFS) advantage vs docetaxel, at a median of 4.4 months (95% CI, 4.2-5.6) vs 3.7 months (95% CI, 2.9-4.2), respectively (HR, 0.75