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It modulates over 4,000 human genes, upregulating collagen (COL1A1) and elastin while downregulating pro-inflammatory cytokines like TGF-1 and IL-6

Therefore, anti-angiogenesis therapy can be used to reverse drug resistance in breast cancer 7

In addition to inducing the main phenotype of ferroptosis, the loss of GPX4 can in some cells trigger apoptosis, necroptosis, pyroptosis, or parthanatos, which mediates or accelerates developmental defects, tissue damage, and sterile inflammation

15 A study has revealed that lipid turnover, the balance between lipid storage and removal, in adipose tissue decreases with age, whether weight loss or gain

Nevertheless, here is the general framework: 1